Lifespan
by David Sinclair, Matthew D. LaPlante · first published 2019
44% recommend51% neutral5% critical
Why HN recommends it
Accessible, well-cited introduction to the science of aging, covering epigenetics and DNA methylation clocks; suits laypeople new to the topic and anyone wanting an optimistic view of slowing aging.
Summarised by Claude from recommending comments
"From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes--the kind that inevitably happens as we get older--makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if ag
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There is a real possibility that in the next few decades some of these therapies might work. The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...
on “Progress of anti-aging therapies by clinical trial stage” ↗If you're interested in changes to aging and the growing science behind it, I can't recommend Lifespan by David Sinclair highly enough.
on “Older people have become younger” ↗For anyone interested in the topic, I'd encourage reading "Lifespan" by David A. Sinclair. As someone with little to no-knowledge about aging (other than feeling the effects of aging on myself) I found it very instructive on how our aging clock works and what are some…
on “In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)” ↗…60-year-old who doesn't. The Horvath clock is useful for evaluating lifestyle changes and your overall healthspan. If people want to learn more about how DNA methylation relates to aging, I recommend reading Lifespan by David Sinclair. [1] https://www.semanticscholar.org/paper/DNA-methylation-aging-...
on “Building an AI to predict human age from a blood sample” ↗Lifespan by David Sinclair would be my recommendation if you want to energise someone for molecular biology/ biotech
on “Ask HN: Which book can attract anyone towards your field of study?” ↗Lifespan: Why We Age-and Why We Don't Have To - David Sinclair [1] [1] https://www.amazon.com/Lifespan-Why-Age-Dont-Have-ebook/dp/B...
on “Ask HN: Books you plan to read in 2020?” ↗If anyone want to know the heads or tails of this, read the book 'Lifespan' by David Sinclair. It has good explanations and awesome research findings on ageing like this study.
on “Two epigenetic regulators interfere with healthy aging” ↗This truly fascinates me... it's the potential for immense extension of human life that no one's talking about. If you're interested in this topic, I highly recommend the book Lifespan by Dr. David Sinclair.
on “Ask HN: What startup/technology is on your 'to watch' list?” ↗…it's a book intro https://www.youtube.com/watch?v=tNn-2TXzSaA * Ageless: The New Science of Getting Older Without Getting Old (Book, not yet released in the US) https://andrewsteele.co.uk/ageless/ * Lifespan: Why we age and why we don't have to (book) https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150... * Google talk: Why We Age and Why We Don't Have To (55:13) - By the author of the book https://www.youtube.com/watch?v=9nXop2lLDa4…
on “Ask HN: What are you surprised isn’t being worked on more?” ↗Lifespan: Why we age and why we don't have to [0] It made me realize we probably can stop aging and age related deceases, which changed my view on life. 0. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...
on “Ask HN: What is the best book you read in 2020?” ↗Peter Attia [1] has a great podcast about many aging/healthspan issues. I listen to the free version but there is also a paid version of the podcast with more info. The book Lifespan [2] from David Sinclair is also a fantastic source. Finally, if you can wade through some of the questionable statements and claims, the book The Longevity Paradox [3] from Steven Gundry does have some…
on “Ask HN: What to do to be healthy when old?” ↗I would read "Lifespan" by David Sinclair, who used Shannon's information theory to model epigenetic changes that cause us to age. Fascinating read and goes to show how far reaching impacts a foundational mathematical theory…
on “Prediction and Entropy of Printed English – Claude Shannon (1950) [pdf]” ↗Dr. David Sinclair (who led this study) has a fascinating book about this topic. He discusses this result and many others from his team, and the theory of epigenetics. Lifespan (2019) by David Sinclair. Also he narrates the audiobook, and he has a very suave and calming voice.
on “Two research teams reverse signs of aging in mice” ↗If you're interested in the science of aging I highly recommend the book "Lifespan: Why we age and why we don't have to" by David A. Sinclair a pioneer in this field. Detailed book with tons of citations but still accessible to the layperson.
on “Diluted blood plasma found to reverse aging in mice” ↗…doing something else, something that helps more. No one said you need to stop all other research and funding, but if we are able to prolong aging diseases you’ll help near everyone on the planet. Give Lifespan by David Sinclair a read
on “Ask HN: What are you surprised isn’t being worked on more?” ↗