Ending Aging
by Aubrey de Grey · first published 2007
78% recommend22% neutral
Why HN recommends it
Accessible, optimistic introduction to de Grey's SENS approach, organizing the many causes of aging into a possible path to solutions; suits lay readers wanting a thorough overview of biogerontology.
Summarised by Claude from recommending comments
MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media o
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…more about what they are doing and why they think their engineering approach has a chance of success, check out Aubrey's book (the paperback version contains a new chapter, afaik): http://www.amazon.com/Ending-Aging-Rejuvenation-Breakthrough... It contains a lot of biology, but should be understandable to the lay person. And if all you want is a really quick intro, check out his TED talk (it's a bit old now (2005),…
on “We will be able to live to 1,000” ↗Please donate generously to the Methuselah Foundation, and check out the book Ending Aging by biogerontologist Aubrey de Grey: http://www.methuselahfoundation.org/
on “What would you do if you knew you couldn't fail?” ↗I highly recommend anyone who is interested in this subject read Aubrey de Grey's book on the current state of the science of biogerontology: http://www.amazon.com/Ending-Aging-Rejuvenation-Breakthrough... It's interesting, thorough, and optimistic. I also recommend donating money to SENS, as this cause is dramatically underfunded relative to its realistic potential to save…
on “Sixty Years Old - is my future short and messy, or long and glorious?” ↗…the dismissal of longevity(/rejuvenation) research in general by the author (and many of the comments here) is incredibly shallow. While Aubrey de Grey highlights his mitochondiral research in his book "Ending Aging"[0], he never claims that it is a silver bullet for aging and most off the book revolves around different parts to the puzzle that have all to be solved in order for consistent rejuvenation to succeed.…
on “The success of Aubrey de Grey baffles me” ↗yes, good stuff. have you looked at aubrey de grey's book on ending aging? also grossman & kurzweil's transcend? there is a tremendous opportunity there in non-institutional health/longevity. one entrepreneurial challenge will be getting a combo of scalability and defensible…
on “Startup Ideas: The Future of Aging” ↗We in fact know a very great deal about stopping aging. This book is a crash course in the science and what it means: http://www.amazon.com/Ending-Aging-Rejuvenation-Breakthrough... If it wasn't illegal to commercially develop ways to treat aging, there would be a lot more progress than has happened to date. http://www.fightaging.org/archives/2010/03/the-roadblock-tha...…
on “Cell-Aging Hack Opens Longevity Research Frontier” ↗…biology of his proposals (and he cites the papers that go even deeper). If you haven't, you don't even know what is being proposed so how can you know if it makes sense or not? http://www.amazon.com/Ending-Aging-Rejuvenation-Breakthrough... I'm sure your public library also has it.
on “How Long Do You Want to Live?” ↗I'm reading Aubrey de Grey's book Ending Aging right now. I'm finding it to be a good read and a great introduction to his approach, SENS (http://www.sens.org).
on “The Hallmarks of Aging (2013)” ↗For a more hopeful picture: Ending Aging, by Aubrey de Grey. He organizes that long list of disparate problems and propose a possible path for their solution. Doesn't make it sound any easier, but at least it is a hopeful reading.
on “New universe of miniproteins is upending cell biology and genetics” ↗If you must read a book, Ending Aging by Aubrey de Grey is maybe the best introduction but IMO you're still better off reading the papers/tracking the latest research if you're interested in the topic. You'll save a lot of time and be more…
on “Older people have become younger” ↗…the foremost expert in the whole field of longevity research as far as I'm concerned, so I don't have any reason to be more or less confident than him about any aspect of it. If you haven't read it, his Ending Aging book covers a lot of details. It was published in 2007 but has still held up, especially with overall strategy. Apart from the various medical developments since then, another encouraging sign is the…
on “People who live past 105 years old have genes that stop DNA damage” ↗> What got you interested in life extension? Immediately when I first heard about it I thought, wow, this is fantastic, because death is a really bad thing. I believe it was mostly reading the book Ending Aging by Aubrey de Grey, although I may have heard about some related ideas on various websites before that. > And how long would you want to live for? Certainly at least a couple hundred years, and by that…
on “Life Is Short (2016)” ↗…attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed! Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060 Transcend: Nine Steps to Living Well Forever…
on “We will be able to live to 1,000” ↗…attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed! Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060 Transcend: Nine Steps to Living Well Forever…
on “We will be able to live to 1,000” ↗…the nucleus and the mitochondria of the cell. This article covers some of the ways that cancer uses mitochondria: https://pmc.ncbi.nlm.nih.gov/articles/PMC4371788/ The best lay introduction I know is "Ending Aging" by Aubrey de Grey and Michael Rae. The book is meant to be an enumeration of all the things that need to be done to biologically reverse aging, but ends up being more than 80% about mitochondria and…
on “Mitochondria Are Alive” ↗