Cancer as a metabolic disease
by Thomas N. Seyfried · first published 2012
82% recommend18% neutral
Why HN recommends it
Argues that cancer stems from faulty cellular energy metabolism, with glucose fermentation replacing oxidative respiration. Its technical, biology-based case is accessible to readers with some background in biology.
Summarised by Claude from recommending comments
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain canc
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Look into Thomas Seyfried's work, e.g. https://www.frontiersin.org/articles/10.3389/fnut.2020.00021... and his book "Cancer as a Metabolic Disease".
on “Study in zebrafish examines how tumors alter whole-body metabolism” ↗If you're a layperson try "Tripping over the Truth" by Travis Christofferson. If you have some biology try "Cancer as a Metabolic Disease" by Seyfried.
on “Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis” ↗This. Read "Tripping over the truth" by Travis Christofferson and "cancer as a metabolic disease" by Seyfried. I'd start with a 3 day water-only fast and then stay low calorie keto for a long time.
on “Ask HN: I Have Cancer. What Should I Do?” ↗For much more information on this argument about sugar and cancer, see the book Cancer as a Metabolic Disease. http://www.amazon.com/Cancer-Metabolic-Disease-Management-Pr...
on “How cancer cells fuel their growth” ↗I have that book, but regret buying it. Frankly, it's lightweight for a HN audience. The original technical book "Cancer as a Metabolic Disease" by Thomas N. Seyfried and published by Wiley seems pretty accessible to me. I'm not advocating for or against the theory. It seems though a lot of time and money has been invested into the genetic…
on “Every Cancer Patient Is One in a Billion” ↗Cancer as a metabolic disease by Prof. Seyfried. Available on Amazon. Good starting point.
on “Europe is now a corporate also-ran. Can it recover its footing?” ↗…pharmaceutical drugs that do more harm than good All in all a gross misunderstanding of what constitutes health and how the human body works. For those so inclined, check out Dr. Thomas Seyfried's work on cancer as a metabolic disease: https://www.bc.edu/bc-web/schools/morrissey/departments/biol...
on “Cancer rates are rising in young people” ↗YSK, cancer as a metabolic disease, and tripping over the truth, are excellent books about this, and why we got cancer wrong since watson and crick.
on “Why cancer cells waste so much energy” ↗There's a long and fascinating story about cancer as a metabolic disease. Turns 98% of modern cancer research on it's head. I wish I could give a 200 word summary, but that would not do justice to the decades of research behind this approach. Instead, I direct you to a book…
on “Researchers discover the microbiome's role in attacking cancerous tumors” ↗Have a read to the book: Cancer as a metabolic disease. I don't know how true is what they claim in the book, but basically it's the following. All cancer cells obtain their energy from fermentation and not oxidation. They use glucose for that fermentation…
on “Antioxidants such as Vitamin C found to spur cancer growth and metastasis” ↗…you cool pictures of where the positron-emitting glucose is in your body, which is where the tumors are. If you fast, your glucose is low and those cells don't survive since there is no glucose. See 'Cancer as a Metabolic Disease' by Seyfried. [warning: The above is not medical orthodoxy, but then medical orthodoxy hasn't made any progress on cancer in ~60 years]
on “Fasting leads to stress resistance, self-renewal, and regeneration (2014)” ↗Here is a video on "Cancer as a Metabolic Disease: Implications for Novel Therapies" [1] by Prof. Thomas Seyfried that may be related. I think their research is very promising. [1] - https://www.youtube.com/watch?v=06e-PwhmSq8 [video]
on “Why cancer cells waste so much energy” ↗I've got the video playing in the background while I work, scanning for references. The first reference is to his own book, "Cancer as a Metabolic Disease", by Thomas Seyfried, John Wiley & Sons, 2012. Presumably he cites many other studies there, I don't know. I'm only about 7 minutes in, but I do also see a reference to Arismendi-Morillo "Int J Biochem…
on “A Ketogenic Diet May be the Key to Cancer Recovery” ↗